A ferritin test helps your doctor understand how much iron your body stores. The protein binds with non ferrous iron in the body and deposits this iron in ferric state, thus providing normal amount of iron whenever needed. Sign Up to Receive Our Free Coroanvirus Newsletter. Intracellular and extracellular ferritin complexes have different ratios of two types of ferritin monomer, the L (light) chain and H (heavy) chain. [35], According to a study of anorexia nervosa patients, ferritin can be elevated during periods of acute malnourishment, perhaps due to iron going into storage as intravascular volume and thus the number of red blood cells falls. Serum ferritin levels of 20-60 µg/L in an anaemic pre-pubescent child may represent iron deficiency if there is coexisting inflammatory disease.

Some types of cancer also can cause your blood ferritin level to be high. Some patients may have trouble when it comes to giving blood samples, especially if their veins are hardly visible or very small in size.

They should avoid antacids, calcium supplements, and tea or coffee within 2 hours of an iron supplement. This content does not have an English version. Ferritin blood test results may come back as normal, low, or high. https://labtestsonline.org/tests/ferritin. Know Your Osteoporosis Blood Test Markers, The Prostate-Specific Antigen (PSA) Blood Test, Creatinine and Creatinine Clearance Blood Tests. A ferritin blood test is a simple blood test to measure the levels of ferritin in a person’s body. Lower-than-normal serum ferritin levels are seen in iron deficiency anemia. https://www.mayocliniclabs.com/test-catalog/Overview/88153. What is a healthy ferritin level? It is unlikely for a person to experience side effects, and when they do occur, they are typically mild.

Accessed Oct. 23, 2019. [20] H and M subunits of eukaryotic ferritin and all subunits of bacterial and archaeal ferritin are H-type and have ferroxidase activity, which is the conversion of iron from the ferrous (Fe2+) to ferric (Fe3+) forms. It is produced in the midgut glands and secreted into the haemolymph, whence it is transported to the eggs.[27]. Ferritin test is very useful way to determine the level of iron present in the human body and doctors use this test in people with symptoms of anemia or hemochromatosis. Any idea if this all is related to ear problems? A ferritin blood test is a simple way to check a person's iron levels. You may also have strange cravings for licorice, chalk, dirt, or clay. ; Low levels of ferritin are indicative of iron deficiency, which causes anemia (a reduction in the number of oxygen-carrying red blood cells). Ferritin is a blood protein that contains iron.

As ferritin accumulates within cells of the reticuloendothelial system, protein aggregates are formed as hemosiderin. Serum ferritin levels of 20-60 µg/L in an anaemic pre-pubescent child may represent iron deficiency if there is coexisting inflammatory disease. There are very few risks involved in ferritin test. If a ferritin test reveals that your blood ferritin level is lower than normal, it indicates your body's iron stores are low and you have iron deficiency. A serum ferritin level <30 µg/L for an adult is diagnostic of iron deficiency. If the ferritin level is low, there is a risk for lack of iron, which could lead to anemia. This is controlled primarily by the amount and stability of messenger RNA (mRNA), but also by changes in how the mRNA is stored and how efficiently it is transcribed. By binding with iron, ferritin is decreasing the toxicity of iron and enables its transportation to the parts of the body which require iron. Ferritin is a protein in blood cells that stores iron. Hyperthyroidism is a medical condition caused by high levels of thyroid hormone in the bloodstream. The ferroxidase activity occurs at a diiron binding site in the middle of each H-type subunits. Individuals should confirm these details with their doctor in the days leading up to the blood test. A doctor may also order other blood tests to discover more about a person’s iron stores. The ferritin test is often ordered as part of a panel of tests that examine the levels of body iron and the effects of abnormalities in iron storage. Lab Tests Online. If your blood sample is being tested only for ferritin, you can eat and drink normally before the test. [12] When a mitochondrion takes it up, it processes it into a mature protein similar to the ferritins found in the cytoplasm, which it assembles to form functional ferritin shells. They may test for: After a doctor takes the blood sample, they will send it to a laboratory for testing. It is responsible for storing iron in the cells.

It is important that people confirm normal levels with their doctor or the laboratory that tested them. For example, ferritins may be high in infection without signaling body iron overload.

Avoid Topical Gels Or Medications With Benzocaine! Furthermore, ferritin has significant non-storage roles within the body, such as protection from oxidative damage. By contrast, organisms such as Pseudomonas, although possessing endotoxin, cause plasma ferritin levels to drop significantly within the first 48 hours of infection. [9] The nature of these subunits varies by class of organism: All the aforementioned ferritins are similar, in terms of their primary sequence, with the vertebrate H-type. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Natural Iron Supplements: Bring Your Hemoglobin and Red Blood Cell Count Levels Up to Normal. All vertebrate ferritin genes have three introns and four exons. [18], Iron is released from ferritin for use by ferritin degradation, which is performed mainly by lysosomes. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Medically reviewed by John A. Daller, MD; American Board of Surgery with subspecialty certification in surgical critical care.

The measurement of ferritin through immunoassay or immunoturbidimeteric methods may also be picking up these isoferritins thus not a true reflection of iron storage status.